In checkerboard and time-kill studies, helvolic acid also exhibited synergistic effects with penicillin, erythromycin and tetracycline. 在棋盘格杀菌以及时间致死曲线的研究中,烟曲霉酸也表现出对青霉素、红霉素、四环素的协同抗细菌耐药活性。
This study aims to identify the functions of post-modification genes of helvolic acid gene cluster and investigate their value in steroid drugs industry. 1. 本研究的目的是研究烟曲霉酸合成基因簇中后修饰基因的功能及其在甾体药物制备中的价值。
The synergistic effect of helvolic acid with penicillin(β-lactam antibiotics) was about 3 times as that of clavulanic acid with penicillin in agar diffusion assay. 在平板扩散法中,烟曲霉酸表现出对青霉素(β-内酰氨抗生素)的协同抗耐药能力,其活性大约3倍于克拉维酸。
Aspergillus fumigatus and Metarhizium anisopliae, fungi which produce steroid antibiotics like helvolic acid, have a great capability for steroid hydroxylation and C1,2 dehydrogenation. 产烟曲霉酸等甾型抗生素的真菌,例如烟曲霉和金龟子绿僵菌等,具有优良的甾体羟化和C1,2位脱氢能力。
Cloning of helvolic acid gene cluster of M. anisopliae and analysis of its gene functions. M. anisopliae, commonly used strain in the hydroxylation reaction of steroid drugs, has a high level of helvolic acid production. 金龟子绿僵菌中烟曲霉酸合成基因簇的克隆和基因功能分析金龟子绿僵菌是甾体药物羟化反应的常用菌,具有较高的烟曲霉酸生产水平。